| Identification | Back Directory | [Name]
GUANYLIN (HUMAN) | [CAS]
183200-12-6 | [Synonyms]
GUANYLIN (HUMAN)
PGTCEICAYAACTGC (DISULFIDE BRIDGE: 4-12 AND 7-15)
PRO-GLY-THR-CYS-GLU-ILE-CYS-ALA-TYR-ALA-ALA-CYS-THR-GLY-CYS
H-PRO-GLY-THR-CYS-GLU-ILE-CYS-ALA-TYR-ALA-ALA-CYS-THR-GLY-CYS-OH
H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH(Cys4-Cys12, Cys7-Cys15)
H-PRO-GLY-THR-CYS-GLU-ILE-CYS-ALA-TYR-ALA-ALA-CYS-THR-GLY-CYS-OH(DISULFIDE BRIDGE: 4-12 AND 7-15)
PRO-GLY-THR-CYS-GLU-ILE-CYS-ALA-TYR-ALA-ALA-CYS-THR- GLY-CYS(DISULFIDE BRIDGE: CYS4-CYS12, CYS7-CYS15) | [Molecular Formula]
C58H87N15O21S4 | [MDL Number]
MFCD00187933 | [MOL File]
183200-12-6.mol | [Molecular Weight]
1458.66 |
| Chemical Properties | Back Directory | [Boiling point ]
1956.4±65.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
White lyophilized powder. | [pka]
2.96±0.70(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism[1][2]. | [storage]
Store at -20°C | [References]
[1] M G Currie, et al. Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):947-51. DOI:10.1073/pnas.89.3.947
[2] J Be?towski. Guanylin and related peptides. J Physiol Pharmacol. 2001 Sep;52(3):351-75. PMID:11596856 |
|
|