| Identification | Back Directory | [Name]
(15R)-BiMatoprost | [CAS]
1163135-92-9 | [Synonyms]
Bimalprost
(15R)-Bimatopros
(15R)-BiMatoprost
15-epi Bimatoprost
Bimatoprost 15-Epimer
Bimatoprost Impurity 1
(15R)- Isomer Bimatoprost
15-epi BiMatoprost ((15R)-BiMatoprost)
Bimatoprost Impurity 1((15R)-Bimatoprost)
Latanoprost and Bimatoprost 15R-bimatoprost
15(R)-17-phenyl trinor Prostaglandin F2α ethyl amide
Latanoprost and Bimatoprost Intermediate 15R-bimatoprost
15(R)-17-phenyl trinor Prostaglandin F2alpha ethyl amide
(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenaMide
5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)-
(15R)-Bimatoprost/15-epi Bimatoprost/(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide | [Molecular Formula]
C25H37NO4 | [MDL Number]
MFCD23115442 | [MOL File]
1163135-92-9.mol | [Molecular Weight]
415.566 |
| Questions And Answer | Back Directory | [Preparation]
The chemical name of (15R)-BiMatoprost is (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-5-N-ethylheptenamide. The typical preparation method involves using benzoyl Corey lactone as the starting material, followed by oxidation, Wittig-Horner reaction, reduction, and hydrolysis to obtain intermediate IV. This intermediate is then directly reacted with a Wittig reaction to obtain crude (15R)-BiMatoprost. Alternatively, (15R)-BiMatoprost acid V can be obtained first through a Wittig reaction, followed by esterification and ammonolysis to obtain crude (15R)-BiMatoprost. Finally, the crude product is purified to obtain the final (15R)-BiMatoprost product. |
| Chemical Properties | Back Directory | [Boiling point ]
629.8±55.0 °C(Predicted) | [density ]
1.145±0.06 g/cm3(Predicted) | [storage temp. ]
Amber Vial, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform, (Sparingly), Methanol (Sparingly) | [form ]
Gel | [pka]
14.25±0.20(Predicted) | [color ]
Colourless | [Stability:]
Light Sensitive | [InChIKey]
AQOKCDNYWBIDND-ZPFRTTICSA-N | [SMILES]
C(NCC)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@H](O)CCC1=CC=CC=C1 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
|