| Identification | Back Directory | [Name]
XL413 (BMS-863233) | [CAS]
1169562-71-3 | [Synonyms]
CS-1062
XL413.HCL
1169562-71-3
BMS-863233 HCl
XL413(BMS-863233)
BMS-863233 HCl salt
BMS-863233 (XL-413)
XL413 (hydrochloride)
XL413 (BMS-863233) HCl
BMS-863233 HCl (XL-413)
BMS-863233 Hydrochloride
XL413 (BMS-863233) USP/EP/BP
XL 413 hydrochloride - BMS 863233 hydrochloride
BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413.
8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one xhydrochloride
Benzofuro[3,2-d]pyrimidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, hydrochloride
8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride (1:?)
Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, (Hydrochloride) (1:)
(4AR,6S,7R,7AS)-6-[4-[[(1S)-2,3-DIHYDRO-1H-INDEN-1-YL]AMINO]PYRROLO[2,3-D]PYRIMIDIN-7-YL]-2-(4-METHOXYPHENYL)-4,4A,5,6,7,7A-HEXAHYDROCYCLOPENTA[D][1,3]DIOXIN-7-OL | [Molecular Formula]
C14H12ClN3O2.x(HCl) | [MDL Number]
MFCD28023577 | [MOL File]
1169562-71-3.mol | [Molecular Weight]
326.178 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: Insoluble;Ethanol: Insoluble | [form ]
powder | [color ]
white to beige | [Water Solubility ]
Water: 46 mg/mL (141.03 mM) | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor. | [Biological Activity]
XL413 hydrochloride is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, its selectivity over CK2, Pim-1 and pMCM2 are 63-, 12- and 35-fold. Phase 1/2. | [in vitro]
In MDA-MB-231T and Colo-205 cell lines,XL413 hydrochloride inhibits CDC7-specific phosphorylation of MCM2. XL413 also inhibited cell proliferation in Colo-205 cells, decreased cell viability, and stimulated caspase 3/7 activity. Furthermore, XL413 resulted in altered S-phase progression and subsequent apoptosis. | [in vivo]
In the Colo-205 xenograft model, XL413, at a dose of 3 mg/kg, inhibited 70% of phosphorylated MCM2 and caused significant regression of tumor growth at a dose of 100 mg/kg. | [target]
| Target | Value | Cdc7
(Cell-free assay) | 3.4 nM | Pim1
(Cell-free assay) | 42 nM | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> CK2
(Cell-free assay) 212 nM |
| [storage]
Store at -20°C |
|
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0.htm |
|