| Identification | Back Directory | [Name]
Tauroursodeoxycholate dihydrate | [CAS]
117609-50-4 | [Synonyms]
UR 906 dihydrate
Taurolite dihydrate)
Tauroursodeoxycholate dihydrate
Tauroursodeoxycholate dihydrate (TUDCA dihydrate
TAUROURSODEOXYCHOLATE DIHYDRATE (TUDCA DIHYDRATE; UR 906 DIHYDRATE; TAUROLITE DIHYDRATE) | [Molecular Formula]
C26H48NO8S- | [MDL Number]
MFCD09750398 | [MOL File]
117609-50-4.mol | [Molecular Weight]
534.726 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (155.54 mM) ,Water:12.5mg/mL(25.02 mM) | [form ]
Solid | [color ]
White to off-white | [InChIKey]
XOSBJJOXVSXOFR-UWHYVWSJNA-N | [SMILES]
C[C@]12CC[C@]3([H])[C@]4(CC[C@@H](O)C[C@@]4([H])C[C@H](O)[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)NCCS(O)(=O)=O)C.O |&1:1,4,6,9,12,15,17,19,23,25,r| |
| Hazard Information | Back Directory | [Uses]
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2]. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C | [References]
[1] Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. DOI:10.1093/cvr/cvr219
[2] Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. DOI:10.1016/j.ejvs.2016.10.026 |
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