| Identification | Back Directory | [Name]
Taurohyodeoxycholic acid sodium salt hydrate | [CAS]
38411-85-7 | [Synonyms]
Taurohyodeoxycholic acid sodium salt hydrate
Taurohyodeoxycholic acid hydrate sodium salt
Sodium taurohyodeoxycholate hydrate,Taurohyodeoxycholic acid sodium salt hydrate | [Molecular Formula]
C26H46NNaO6S | [MDL Number]
MFCD00271496 | [MOL File]
38411-85-7.mol | [Molecular Weight]
523.7 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid . THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats. Co-administration of THDCA with taurochenodeoxycholic acid (TCDCA; ) prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats. THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis. | [Uses]
Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions. | [General Description]
Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent. |
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