| Identification | Back Directory | [Name]
Levofloxacin N-oxide | [CAS]
117678-38-3 | [Synonyms]
Levofloxacin-3
(S)-4-(6-carboxy-9
Levofloxacin N-oxide
Levofloacin Impurity 2
Levofloxacin N-Oxide 1
levofloxacin N-oxide832
Levofloxacin BP Impurity C
Levofloxacin nitrogen oxide
USP Levofloxacin Related Compound C
Levofloxacin Impurity C（Levofloxacin N-oxide）
Levofloxacin N-Oxide（Levofloxacin EP Impurity C）
Levofloxacin EP Impurity C (Levofloxacin N-Oxide)
Levofloxacin impurity 7/Levofloxacin N-oxide/Levofloxacin EP Impurity C
(S)-4-(6-carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-10-yl)-1-methylpiperazine 1-oxide
(S)-4-(6-carboxy-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinolin-10-yl)-1-methylpiperazine 1-oxide
1-Methyl-4-[(9-fluoro-2,3-dihydro-6-carboxy-3α-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazin)-10-yl]piperazine 1-oxide
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-4-oxido-1-piperazinyl)-7-oxo-, (3S)-
(S)-4-(6-Carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-10-yl)-1-methylpiperazine 1-oxide (Levofloxacin N-Oxide)
Levofloxacin N-oxideQ: What is
Levofloxacin N-oxide Q: What is the CAS Number of
Levofloxacin N-oxide Q: What is the storage condition of
Levofloxacin N-oxide | [Molecular Formula]
C18H20FN3O5 | [MDL Number]
MFCD24386420 | [MOL File]
117678-38-3.mol | [Molecular Weight]
377.367 |
| Chemical Properties | Back Directory | [Melting point ]
>146°C (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
5.19±0.40(Predicted) | [color ]
Off-White to Pale Green | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C18H20FN3O5/c1-10-9-27-17-14-11(16(23)12(18(24)25)8-21(10)14)7-13(19)15(17)20-3-5-22(2,26)6-4-20/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1 | [InChIKey]
MVLAUMUQGRQERL-JTQLQIEISA-N | [SMILES]
O1C2=C(N3CC[N+]([O-])(C)CC3)C(F)=CC3C(=O)C(C(O)=O)=CN(C2=3)[C@@H](C)C1 |
| Hazard Information | Back Directory | [Description]
Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin . Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide. | [Uses]
Levofloxacin N-oxide is an impurity of Ofloxacin (O245750), which is a fluorinated quinolone antibacterial. | [References]
[1] A HEMERYCK. Pharmacokinetics, metabolism, excretion and plasma protein binding of 14C-levofloxacin after a single oral administration in the Rhesus monkey.[J]. Xenobiotica, 2006, 36 7: 597-613. DOI: 10.1080/00498250600674436
[2] Levofloxacin[J]. Reactions Weekly, 2018, 17 1: 232. DOI: 10.1007/s40278-018-53210-y
[3] ANDRZEJ CZYRSKI Artur T Katarzyna Anusiak. The degradation of levofloxacin in infusions exposed to daylight with an identification of a degradation product with HPLC-MS.[J]. Scientific Reports, 2019: 3621. DOI: 10.1038/s41598-019-40201-9
[4] M. LALITHA DEVI K. B C. A validated stability-indicating RP-HPLC method for levofloxacin in the presence of degradation products, its process related impurities and identification of oxidative degradant[J]. Journal of pharmaceutical and biomedical analysis, 2009, 50 5: Pages 710-717. DOI: 10.1016/j.jpba.2009.05.038 |
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