| Identification | Back Directory | [Name]
(3S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid monohydrochloride | [CAS]
177325-13-2 | [Synonyms]
Levofloxacin hydroch
LEVOFLOXACIN HYDROCHLORIDE
Levofloxacin white powder Antibacterial
-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)
usp27 99% Levofloxacin white powder Antibacterial
-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride
(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride
3S)-9-Fluoro-2,3-dihydro-3-Methyl-10-(4-Methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid Monohydrochlori
(3S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid monohydrochloride
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 9-fluoro-2,3-dihydro-3-Methyl-10-(4-Methyl-1-piperazinyl)-7-oxo-,hydrochloride (1:1), (3S)- | [EINECS(EC#)]
605-797-4 | [Molecular Formula]
C18H20FN3O4.HCl | [MDL Number]
MFCD03265511 | [MOL File]
177325-13-2.mol | [Molecular Weight]
397.83 |
| Questions And Answer | Back Directory | [Preparation]
The existing synthesis process for levofloxacin hydrochloride involves a condensation reaction of levofluorocarboxylic acid and N-methylpiperazine under a catalyst to produce levofloxacin. The solvent is then evaporated, and the product is crystallized in a crystallization solvent and dried to obtain dried levofloxacin. Finally, levofloxacin is salted with hydrochloric acid and crystallized multiple times with ethanol to obtain levofloxacin hydrochloride. The existing synthesis process has the following problems: 1) It requires the prior preparation of levofloxacin crystals before salting with hydrochloric acid, making the process lengthy, cumbersome, and difficult to operate; 2) The use of a catalyst in the preparation of levofloxacin introduces impurities, resulting in low purity of the final levofloxacin hydrochloride, requiring further purification. |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Aqueous Base (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [color ]
White to Pale Beige |
| Hazard Information | Back Directory | [Uses]
Levofloxacin Hydrochloride is a fluoroquinolone broad spectrum antibiotic. It is an inhibitor of two enzymes, DNA gyrase and topoisomerase IV. | [IC 50]
TOPO IV |
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