| Identification | Back Directory | [Name]
6-bromoimidazo[1,2-a]pyrazin-8-amine | [CAS]
117718-84-0 | [Synonyms]
PAB 12
2-a]pyrazin-8-aMine
8-bromoimidazo[1,2-a]pyrazin-6-amine
6-bromo-8-imidazo[1,2-a]pyrazinamine
6-bromoimidazo[1,2-a]pyrazin-8-amine
8-Amino-6-bromoimidazo[1,2-a]pyrazine
6-Bromo-8-aminoimidazo[1,2-a]pyrazine
Imidazo[1,2-a]pyrazin-8-amine,6-bromo- | [Molecular Formula]
C6H5BrN4 | [MDL Number]
MFCD00874115
| [MOL File]
117718-84-0.mol | [Molecular Weight]
213.03 |
| Questions And Answer | Back Directory | [Application]
6-bromoimidazo[1,2-a]pyrazin-8-amine are a type of synthetic building block with strong pharmacological activity among nitrogen-containing heterocyclic compounds. Heterocyclic compounds are a class of small molecule compounds with strong biological activity and are widely used in fields such as biomedicine, pesticides, and optoelectronic materials. In particular, 6-haloimidazo[1,2-A]pyrazine active small molecule compounds are a research hotspot for major pharmaceutical companies. |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 6-bromoimidazo[1,2-A]pyrazin-8-amine from 6,8-dibromo-imidazo[1,2-A]pyrazine: The product obtained from the preparation of Example 29 (1.80 g, 6.45 mmol) was mixed with concentrated aqueous NH4OH solution (27.0 mL) in a closed pressure vessel and reacted with stirring for 24 hrs at 90 °C. Upon completion of the reaction, the solvent was removed by evaporation and the resulting residue was purified by silica gel column chromatography with EtOAc as eluent. A white solid product (1.01 g, 73% yield) was finally obtained.LCMS analysis showed that MH+ = 213. | [References]
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 18, p. 3353 - 3358
[2] Patent: US2004/63715, 2004, A1. Location in patent: Page/Page column 27
[3] Patent: WO2004/22562, 2004, A1. Location in patent: Page 28 |
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