| Identification | Back Directory | [Name]
DOFETILIDE-D4 | [CAS]
1189700-56-8 | [Synonyms]
Tikosyn-d
Tikosyn-d4
UK-68798-d4
DOFETILIDE-D4
N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide-d4 | [Molecular Formula]
C19H27N3O5S2 | [MDL Number]
MFCD09840517 | [MOL File]
1189700-56-8.mol | [Molecular Weight]
441.565 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
130-1350C | [storage temp. ]
-20?C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White | [CAS DataBase Reference]
1189700-56-8 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
Labeled Dofitilide, intended for use as an internal standard for the quantification of Dofitilide by GC- or LC-mass spectrometry. | [Uses]
Potassium channel blocker | [Description]
Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg. Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm. | [storage]
Store at -20°C | [References]
[1] N K JURKIEWICZ M C S. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide.[J]. Circulation research, 1993, 72 1: 75-83. DOI: 10.1161/01.res.72.1.75
[2] L NALOS. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes[J]. British Journal of Pharmacology, 2011, 165 2: 467-478. DOI: 10.1111/j.1476-5381.2011.01558.x
[3] ALBERT DUNNINK. Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog.[J]. Europace, 2012, 14 3: 431-436. DOI: 10.1093/europace/eur311 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|