| Identification | Back Directory | [Name]
Amiodarone-D4 HCl | [CAS]
1216715-80-8 | [Synonyms]
Amiodarone hydrochloride salt
[2H4]-Amiodarone Hydrochloride
Amiodarone-D4 hydrochloride solution
AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE)
(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride
Amiodarone D4 HydrochlorideQ: What is
Amiodarone D4 Hydrochloride Q: What is the CAS Number of
Amiodarone D4 Hydrochloride Q: What is the storage condition of
Amiodarone D4 Hydrochloride Q: What are the applications of
Amiodarone D4 Hydrochloride | [EINECS(EC#)]
806-400-9 | [Molecular Formula]
C25H30ClI2NO3 | [MDL Number]
MFCD08064189 | [MOL File]
1216715-80-8.mol | [Molecular Weight]
681.78 |
| Hazard Information | Back Directory | [Description]
Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations. | [Uses]
A Labelled non-selective ion channel blocker. Antiarrhythmic (class III). | [General Description]
A Certified Spiking Solution?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone?, Cordarone?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range. | [storage]
Store at -20°C |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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http://www.energy-chemical.com |
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