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1189767-28-9

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1189767-28-9 Structure

1189767-28-9 Structure
IdentificationBack Directory
[Name]

BI-409306
[CAS]

1189767-28-9
[Synonyms]

CS-2883
BI-409306
BI 409306 (BI-409306
BI 409306;BI-409306;BI409306
6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-6-(2-pyridinylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-
[EINECS(EC#)]

810-297-6
[Molecular Formula]

C16H17N5O2
[MDL Number]

MFCD31746892
[MOL File]

1189767-28-9.mol
[Molecular Weight]

311.34
Chemical PropertiesBack Directory
[Boiling point ]

559.8±60.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:62.0(Max Conc. mg/mL);199.14(Max Conc. mM)
[form ]

A crystalline solid
[pka]

3.94±0.12(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
Hazard InformationBack Directory
[Uses]

Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.
[IC 50]

PDE9A: 52 nM (IC50); PDE1C: 1 μM (IC50); PDE1A: 1.4 μM (IC50)
[storage]

Store at -20°C
[References]

[1] Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research.
Spectrum DetailBack Directory
[Spectrum Detail]

BI-409306(1189767-28-9)1HNMR
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