| Identification | Back Directory | [Name]
BuforMin Hydrochloride | [CAS]
1190-53-0 | [Synonyms]
Adebit
Andere
Biforon
TideMol
Ziavetine
PanforMin
Sindiatil
NSC528218
NSC-528218
NSC 528218
Aids126511
Aids-126511
BUFORMINE HCL
Dibetos-B (TN)
n-butylbiguanideHCl
buformin hydrochloride
BUFORMINE HYDROCHLORIDE
Buformin hydrochloride (JAN)
BUTYL-BIGUANIDE HYDROCHLORIDE
1-Butylbiguanide Hydrochloride
N-BUTYL BIGUANIDE HYDROCHLORIDE
1-Butylbigyanidine hydrochloride
BuforMin Hydrochloride USP/EP/BP
1-butylbiguanide monohydrochloride
Biguanide, 1-butyl-, hydrochloride
N-ButylidodicarboniMidic DiaMide Hydrochloride
1-Butyl-3-carbamimidoyl-guanidine hydrochloride
N-butylimidodicarbonimidic diamide hydrochloride
Buformin hydrochloride solution in Methanol，100μg/mL
Imidodicarbonimidic diamide, N-butyl-, hydrochloride (1:1)
Buformin HclQ: What is
Buformin Hcl Q: What is the CAS Number of
Buformin Hcl Q: What is the storage condition of
Buformin Hcl Q: What are the applications of
Buformin Hcl | [EINECS(EC#)]
214-723-6 | [Molecular Formula]
C6H16ClN5 | [MDL Number]
MFCD00045591 | [MOL File]
1190-53-0.mol | [Molecular Weight]
193.68 |
| Chemical Properties | Back Directory | [Melting point ]
177-179?C | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic | [CAS DataBase Reference]
1190-53-0 |
| Hazard Information | Back Directory | [Description]
Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells. | [Chemical Properties]
White Solid | [Originator]
Silubin,Protochemie,Switz. | [Uses]
BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
| [Uses]
Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. | [Manufacturing Process]
105.6 g of n-butylamine hydrochloride and 79.3 g of dicyandiamide were
ground intimately and mixed. The mixture was heated by means of an oil
bath, gradually with stirring, and after thirty minutes when the internal
temperature had reached 150°C, an exothermic reaction ensued with internal
pressure rising to 178°C. The reaction mixture was removed from the oil bath
until the internal temperature had fallen to 150°C and then heating was
resumed at 150°C for one hour. The cooled fusion mixture was dissolved in 3
liters of acetonitrile and on cooling n-butyl-biguanide hydrochloride precipitated. | [Therapeutic Function]
Antidiabetic | [storage]
Store at -20°C |
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