| Identification | Back Directory | [Name]
Cholestane-3,5-diol, 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-, (3β,5α,6β)- | [CAS]
1191043-85-2 | [Synonyms]
Dendrogenin A
Cholestane-3,5-diol, 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-, (3β,5α,6β)- | [Molecular Formula]
C32H55N3O2 | [MOL File]
1191043-85-2.mol | [Molecular Weight]
513.8 |
| Chemical Properties | Back Directory | [Boiling point ]
665.4±55.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 30 mg/ml | [pka]
14.08±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 μM. Dendrogenin A arrests the cell cycle at G0/G1 phase[1]. | [References]
[1] Bauriaud-Mallet M, et al., The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells. J Steroid Biochem Mol Biol. 2019 Sep;192:105390. DOI:10.1016/j.jsbmb.2019.105390 |
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