| Chemical Properties | Back Directory | [Melting point ]
189.5-190 °C | [Boiling point ]
525.6±23.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 1 mg/ml | [form ]
A solid | [pka]
15.03±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DMHCA has been used as LXR activator to tre at retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.', 'It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor. | [Biological Activity]
N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosisage-related macular degeneration and diabetic retinopathy.''DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transportexpression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulationinduced by oxysterol. | [in vivo]
DMHCA (oral administration; 6 months; chow 8mg/kg body weight /day) restores cholesterol homeostasis in diabetic retina. It significantly increases endogenous LXR ligands, desmosterol, and total oxysterols in the diabetic retina[1]. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|