| Identification | Back Directory | [Name]
Dichloro-1,2-dithiacyclopentenone | [CAS]
1192-52-5 | [Synonyms]
DDCP
2,2-Diphenyl-3-butynamide
4,5-dichlorodithiol-3-one
dichloro-1,2-dithiol-3-one
4,5-Dichloro-1,2-dithiol-3-one
4,5-dichloro-3-oxo-1,2-dithiole
Dichloro-1,2-dihiacyclopenenone
4,5-Dichlor-3H-1,2-dithiol-3-on
4,5-dichloro-3h-2-dithiole-3-one
dichloro-1,2-dithiacyclopentenone
4,5-DICHLORO-3H-1,2-DITHIOL-3-ONE
4,5-dichloro-3h-1,2-dithiole-3-one
4,5-dichloro(3H)-1,2-dithiol-2-one
3H-1,2-Dithiol-3-one, 4,5-dichloro-
spectrum rx3127 and spectrum rx7844
4,5-Dichloro-3H-1,2-dithiol-3-one 98%
4,5-Dichloro-1,2-
dithiacyclopentenone
4,5-Dichloro-3H-1,2-dithiolcyclopentene-3-one
Dichloro-1,2-dithiacyclopentenone in stock Factory
2,3-dichloro-1$l^{4},2$l^{4}-dithiacyclopent-2-ene 1-oxide | [EINECS(EC#)]
214-754-5 | [Molecular Formula]
C3Cl2OS2 | [MDL Number]
MFCD00043025 | [MOL File]
1192-52-5.mol | [Molecular Weight]
187.07 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-37/38 | [Safety Statements ]
36/37/39-45 | [RIDADR ]
2811 | [WGK Germany ]
3 | [RTECS ]
JP1290000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Toxicity]
mouse,LD50,intravenous,13mg/kg (13mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07423, |
| Hazard Information | Back Directory | [Uses]
4,5-Dichloro-3H-1,2-dithiol-3-one (Dichloro-1,2-dithiacyclopentenone) is an E. coli FabH inhibitor (IC50: 2.9 μM). 4,5-Dichloro-3H-1,2-dithiol-3-one can be used as a slimicide in the manufacture of food-contact paper and paperboard [1][2]. | [Synthesis]
Using tetrachloroethylene and trichloromethane as the starting materials, 4,5-dichloro-1,2-dithiolenone was obtained by Foucault reaction, alkaline dechlorination to alkene, and catalytic and sulfur cyclization. | [Purification Methods]
Dissolve it in CH2Cl2 (1g in 250ml), filter, wash it twice with H2O, evaporate and distil the residue in vacuo and then recrystallise it from pet ether. IR: max 1650 cm-1. [Boberg Justus Liebigs Ann Chem 679 109 1964, Boberg Justus Liebigs Ann Chem 693 212 1966, Beilstein 19/4 V 72.] | [References]
[1] Song X, et al. Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitor. Chem Pharm Bull (Tokyo). 2014;62(11):1110-8. DOI:10.1248/cpb.c14-00485
[2] Mary S. Wolfe, et al. Chapter. National Toxicology Program. Book. Toxicology and Regulatory Process. 2006. Pages. 32 |
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