| Identification | Back Directory | [Name]
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER | [CAS]
119285-07-3 | [Synonyms]
Palbociclib Impurity 42
Palbociclib Impurity 103
1-Boc-4-(5-amino-2-pyridinyl)-piperazine
1-BOC-4-(5-AMINO-PYRIDIN-2-YL)-PIPERAZINE
4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected
tert-butyl 3-allyl-3-hydroxyazetidine-43-carboxylate
4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected 95%
1-(tert-Butyloxycarbonyl)-4-(5-aminopyridin-2-yl)piperazine
ert-Butyl4-(5-amino-2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxylate
4-(5-amino-2-pyridinyl)-2-piperazinecarboxylic acid tert-butyl ester
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-(5-Aminopyridin-2-yl)piperazine-1-carboxylicacidtert-butylester95%
4-(5-Aminopyridin-2-yl)qiperazine-1-carboxylic acid tert-butyl ester
TERT-BUTYL 4-(5-AMINO-2-PYRIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%
1-Piperazinecarboxylic acid, 4-(5-amino-2-pyridinyl)-, 1,1-dimethylethyl ester
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH | [Molecular Formula]
C14H22N4O2 | [MDL Number]
MFCD05864841 | [MOL File]
119285-07-3.mol | [Molecular Weight]
278.35 |
| Chemical Properties | Back Directory | [Melting point ]
98-101°C | [Boiling point ]
470.4±45.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [form ]
solid | [pka]
9.35±0.29(Predicted) | [color ]
black gel |
| Hazard Information | Back Directory | [Synthesis]
Example 197b Synthesis of tert-butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate 197b: To a 250-mL round-bottomed flask under nitrogen protection was added 1-tert-butylcarbonyl-4-(5-nitro-2-piperidinyl)piperazine 197a (4.0 g, 13.0 mmol), 10% palladium-carbon (wetted, 500 mg) and methanol (130 mL). The reaction system was evacuated and filled with hydrogen and the reaction was stirred at room temperature for 15 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and filled with nitrogen. The reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure to afford the target compound 197b (3.3 g, 91% yield). Mass spectral data (MS-ESI): [M + H]+ 279. | [References]
[1] Patent: US2005/182078, 2005, A1. Location in patent: Page/Page column 9; 12
[2] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 14
[3] Chinese Chemical Letters, 2013, vol. 24, # 4, p. 303 - 306
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 16, p. 4779 - 4783
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0753; 0755 |
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