| Identification | Back Directory | [Name]
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride | [CAS]
119770-60-4 | [Synonyms]
Des Loratadine methanone
Loratadine Methyl Ketone
Loratadine Impurity 10 HCl
Loratadine Methanone Impurity
(3-(3-chlorophenethyl)pyridin-
Desloratadine Methanone Impurity
(3-(3-Chlorophenethyl)pyridin-2-yl)(1-methyl-piperidin-4-yl)methanone hydrochloride
{3-[2-(3-Chlorophenyl)ethyl]pyridine-2-yl}-(1-methyl?piperidine-4-yl) (Methonal HCL)
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
[3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl](1-methyl-4-piperidinyl)methanone hydrochloride
[3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl]-(1-methylpiperidin-4-yl)methanone:hydrochloride
Loratadine Impurity ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone)
Desloratadine Impurity 3/Desloratadine Methanone Impurity HCl/Desloratadine Ketone Impurity HCl
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride ISO 9001：2015 REACH | [Molecular Formula]
C20H24Cl2N2O | [MDL Number]
MFCD08063842 | [MOL File]
119770-60-4.mol | [Molecular Weight]
379.32 |
| Chemical Properties | Back Directory | [Melting point ]
183-185 °C | [InChI]
InChI=1S/C20H23ClN2O.ClH/c1-23-12-9-17(10-13-23)20(24)19-16(5-3-11-22-19)8-7-15-4-2-6-18(21)14-15;/h2-6,11,14,17H,7-10,12-13H2,1H3;1H | [InChIKey]
YDOROGMYGIAIPT-UHFFFAOYSA-N | [SMILES]
C(C1CCN(C)CC1)(C1=NC=CC=C1CCC1=CC=CC(Cl)=C1)=O.[H]Cl |
| Hazard Information | Back Directory | [Uses]
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is an important fine chemical, Desloratadine methanone impurity, which can be used in organic synthetic materials or chemical research. | [Synthesis]
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is prepared by the reaction of 4-chloro-1-methylpiperidine and 3-(3-chlorophenethyl)picolinonitrile. The specific synthesis steps are as follows:
Add magnesium (3.6g) and a small amount of iodine into the reaction flask under nitrogen protection,Add re-distilled THF (20ml), 1,2-dibromoethane (1ml), 4-chloro-N-methylpiperidine (1ml), and stir at 75°C; after the liquid surface of the system is foamed, add 4- Chloro-N-methylpiperidine (20.4ml) was dissolved in THF (240ml) and slowly added dropwise. After the dropwise addition, it was reacted for 1h and cooled to room temperature for later use. Compound V (26.0g, 107mmol) was dissolved in THF (250ml) under nitrogen protection;Add the prepared Grignard reagent dropwise to the reaction flask at room temperature to control the temperature of the system; after the dropwise addition, control the temperature of the system at 40-50°C and continue the reaction for 1 hour. After the reaction is completed, adjust the pH of the reaction solution to below 2 with a 2mol/L HCl solution, and continue the reaction at room temperature for 1 hour; after the reaction is completed, THF is distilled off under reduced pressure, and then the pH value of the solution is adjusted with a 50% NaOH solution. Adjust to 3-4, crystallize in an ice-water bath, filter and wash, and dry the solid to obtain a pale yellow powder ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride, 33.8 g, 83.3%).
![(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride synthesis](/NewsImg/2024-01-08/6384033139696020939320129.png "(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride synthesis") |
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