| Identification | More | [Name]
Propionyl-L-carnitine hydrochloride | [CAS]
119793-66-7 | [Synonyms]
PROPIONYL-L-CARNITINE CHLORIDE
PROPIONYL L-CARNITINE HCL
PROPIONYL-L-CARNITINE HYDROCHLORIDE
PROPIONYL-LEVO-CARNITINE HYDROCHLORIDE
(r)-2-propionyl-3-(trimethylaminium)butanoic acid chloride
Propionyl L-Carnitine
PROPIONYLLEVOCARNITINE HCL
Propionyllevocarnitine
L-Propionylcarnitine chloride
(R)-3-Carboxylato-2-propionyloxy-N,N,N-trimethyl-1-propanaminium
(R)-N,N,N-Trimethyl-3-carboxylato-2-propanoyloxy-1-propaneaminium | [EINECS(EC#)]
922-939-3 | [Molecular Formula]
C10H20ClNO4 | [MDL Number]
MFCD00274137 | [Molecular Weight]
253.72 | [MOL File]
119793-66-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
165-167°C | [storage temp. ]
Store at 0°C | [solubility ]
Chloroform (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Appearance]
white solid | [Odor]
Mild, slightly sweet odor | [Stability:]
Hygroscopic | [Cosmetics Ingredients Functions]
EMULSION STABILISING | [InChI]
InChI=1/C10H19NO4.ClH/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4;/h8H,5-7H2,1-4H3;1H/t8-;/s3 | [InChIKey]
KTFMPDDJYRFWQE-JNODIIHCNA-N | [SMILES]
[C@@H](CC(=O)O)(C[N+](C)(C)C)OC(=O)CC.[Cl-] |&1:0,r| | [CAS DataBase Reference]
119793-66-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.1 Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto-prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.1 It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.2 Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.3 | [Chemical Properties]
White Solid | [Uses]
antihypertensive | [Uses]
L-Propionyl carnitine has been shown to improve the heart''s mechanical recovery and other metabolic parameters after ischemia-reperfusion. | [Uses]
L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion. | [Brand name]
Dromos (Biosint S.p.A.). | [storage]
Store at -20°C | [References]
[1] I M GARRELDS. Effects of carnitine and its congeners on eicosanoid discharge from rat cells: implications for release of TNFalpha.[J]. Mediators of Inflammation, 1993, 2 7: S57-62. DOI: 10.1155/s0962935193000778
[2] MARIA ANTONIETTA STASI. Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010, 30 3: 426-435. DOI: 10.1161/atvbaha.109.201533
[3] R FERRARI. The effect of propionyl-L-carnitine on the ischemic and reperfused intact myocardium and on their derived mitochondria.[J]. Cardiovascular Drugs and Therapy, 1991, 5 Suppl 1: 57-65. DOI: 10.1007/bf00128244 |
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J & K SCIENTIFIC LTD.
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Jia Xing Isenchem Co.,Ltd
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Maya High Purity Chemicals
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