| Identification | Back Directory | [Name]
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol | [CAS]
1198357-79-7 | [Synonyms]
ETP 45658
3-(1-Methyl-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Inhibitor,PI3K,breast,DNA-PK,Mammalian target of Rapamycin,DNA-dependent protein kinase,mTOR,inhibit,Phosphoinositide 3-kinase,ETP-45658,cancer | [Molecular Formula]
C16H17N5O2 | [MDL Number]
MFCD29081201 | [MOL File]
1198357-79-7.mol | [Molecular Weight]
311.34 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.18±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ETP 45658 is a potent and selective inhibitor of phosphoinositol 3-kinase and demonstrates mechanism of action in tumor cells, inhibitors of mTOR kinase as antiviral agents. | [in vivo]
ETP-45658 (22.7 mg/kg) decreases the level of phosphorylated Akt on serine 473 in the mammary ducts of transgenic mice[1]. | [IC 50]
PI3Kα: 22.0 nM (IC50); PI3Kδ: 39.8 nM (IC50); PI3Kβ: 129.0 nM (IC50); PI3Kγ: 717.3 nM (IC50); DNA-PK: 70.6 nM (IC50); mTOR: 152.0 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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