| Identification | Back Directory | [Name]
N-Boc-L-homoserine Methyl Ester | [CAS]
120042-11-7 | [Synonyms]
N-Boc-L-homoserine Methyl Ester
N-[(1,1-Dimethylethoxy)carbonyl]-L-homoserine Methyl Ester
tert-butyl (S)-1-(methoxycarbonyl)-3-hydroxypropylcarbamate
L-Homoserine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-4-hydroxybutanoate
(S)-2-(tert-Butoxycarbonylamino)-4-hydroxybutyric Acid Methyl Este
methyl (2S)-4-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate | [Molecular Formula]
C10H19NO5 | [MDL Number]
MFCD09835542 | [MOL File]
120042-11-7.mol | [Molecular Weight]
233.26 |
| Chemical Properties | Back Directory | [Boiling point ]
364.6±37.0 °C(Predicted) | [density ]
1.125±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [pka]
10.91±0.46(Predicted) | [Appearance]
Colorless to light yellow Viscous Liquid |
| Hazard Information | Back Directory | [Synthesis]
To a solution of (S)-2-(tert-butoxycarbonylamino)-4-hydroxybutyric acid 206 (8.5 g, 38 mmol) in DMF (50 mL) was added K2CO3 (5.24 g, 38 mmol) and iodomethane (5.4 g, 38 mmol). The reaction mixture was stirred at room temperature overnight. After the reaction was completed, the reaction mixture was diluted with water (500 mL) and extracted with dichloromethane (500 mL). The organic layers were combined, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure to remove the solvent to afford the crude product (S)-2-((tert-butoxycarbonyl)amino)-4-hydroxybutyric acid methyl ester 207 (8.5 g, 90% yield). | [References]
[1] Patent: WO2017/189866, 2017, A1. Location in patent: Paragraph 0243
[2] Patent: WO2017/156074, 2017, A1. Location in patent: Paragraph 00494
[3] Biochemistry, 2017, vol. 56, # 8, p. 1062 - 1074
[4] Patent: WO2016/112088, 2016, A1. Location in patent: Paragraph 0481 |
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