| Identification | Back Directory | [Name]
ThioLox | [CAS]
1202193-89-2 | [Synonyms]
ThioLox
ThioLox - Thiophene A9
3-Thiophenecarboxamide, 2-amino-N-butyl-5-phenyl- | [Molecular Formula]
C15H18N2OS | [MOL File]
1202193-89-2.mol | [Molecular Weight]
274.38 |
| Chemical Properties | Back Directory | [Boiling point ]
460.6±45.0 °C(Predicted) | [density ]
1.160±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 30 mg/ml | [form ]
Solid | [pka]
14.44±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties[1]. | [in vivo]
ThioLox has a logP of 3 and shows values that comply very well with the BBB permeability[1]. | [References]
[1] Eleftheriadis N, et al. Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur J Med Chem. 2016 Oct 21;122:786-801. DOI:10.1016/j.ejmech.2016.07.010 |
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