| Identification | Back Directory | [Name]
(2E,4E)-5-(4-methoxyphenyl)-N-[(2R)-5-pyridin-3-ylpentan-2-yl]deca-2,4 -dienamide | [CAS]
120555-31-9 | [Synonyms]
Ro 24-0238
(2E,4E)-5-(4-methoxyphenyl)-N-[(2R)-5-pyridin-3-ylpentan-2-yl]deca-2,4 -dienamide
(2E,4E)-5-(4-Methoxyphenyl)-N-[(R)-1-methyl-4-(3-pyridinyl)butyl]-2,4-decadienamide
2,4-Decadienamide, 5-(4-methoxyphenyl)-N-[(1R)-1-methyl-4-(3-pyridinyl)butyl]-, (2E,4E)- | [Molecular Formula]
C27H36N2O2 | [MDL Number]
MFCD00884705 | [MOL File]
120555-31-9.mol | [Molecular Weight]
420.59 |
| Chemical Properties | Back Directory | [Melting point ]
88-89 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3)) | [Boiling point ]
627.1±55.0 °C(Predicted) | [density ]
1.026±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
14.07±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF. | [in vivo]
Pretreatment with 3 mg/kg Ro 24-0238 and 3 mg/kg WEB 2086 decreases the accumulation of neutrophils within the mucosa in rats[1]. | [storage]
Store at -20°C | [References]
[1] Will PC, et al. Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. Agents Actions. 1991 Sep;34(1-2):181-4. DOI:10.1007/BF01993272 |
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