| Identification | More | [Name]
BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE | [CAS]
12083-48-6 | [Synonyms]
BIS(CYCLOPENTADIENYL)VANADIUM CHLORIDE
BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE
BIS(CYCLOPENTADIENYL)VANADIUM(IV) DICHLORIDE
DICYCLOPENTADIENYL VANADIUM DICHLORIDE
VANADINOCENE DICHLORIDE
VANADOCENE CHLORIDE
VANADOCENE DICHLORIDE
dichlorodi-pi-cyclopentadienyl-vanadiu
dichlorodi-pi-cyclopentadienylvanadium
dichlorovanadocene
Bis(cyclopentadienyl)vanadium dichloride (Vanadocene dichloride)
dichlorobis(eta5-cyclopenta-2,4-dien-1-yl)vanadium
Bis(cyclopentadienyl)vanadiumdichloride(Vanadocenedichloride),95% | [EINECS(EC#)]
235-150-8 | [Molecular Formula]
C10H10Cl2V 10* | [MDL Number]
MFCD00014260 | [Molecular Weight]
252.03 | [MOL File]
12083-48-6.mol |
| Chemical Properties | Back Directory | [Appearance]
dark green crystalline powder | [Melting point ]
182-194 °C (dec.)(lit.) | [density ]
1,6 g/cm3 | [storage temp. ]
Refrigerator (+4°C) | [solubility ]
soluble in H2O, chloroform, ethanol | [form ]
crystal | [color ]
green | [Specific Gravity]
1.6 | [Water Solubility ]
Reacts with water | [Sensitive ]
Air & Moisture Sensitive | [Exposure limits]
NIOSH: Ceiling 0.05 mg/m3 | [InChI]
1S/2C5H5.2ClH.V/c2*1-2-4-5-3-1;;;/h2*1-5H;2*1H;/q;;;;+2/p-2 | [InChIKey]
MDWJZZZKWHLMQP-UHFFFAOYSA-L | [SMILES]
Cl[V]Cl.[CH]1[CH][CH][CH][CH]1.[CH]2[CH][CH][CH][CH]2 | [CAS DataBase Reference]
12083-48-6(CAS DataBase Reference) | [EPA Substance Registry System]
Vanadocene dichloride (12083-48-6) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3285 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
YW1580000
| [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29310099 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [General Description]
Pale green crystals or green powder. | [Reactivity Profile]
Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE(12083-48-6), are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water. | [Air & Water Reactions]
Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water | [Fire Hazard]
Flash point data for this chemical are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible. | [Chemical Properties]
dark green crystalline powder | [Uses]
Bis(cyclopentadienyl)vanadium(IV) dichloride is a catalyst for solvent free, room temperature preparation of vicinal amino alcohols as fungistatic agents, catalyst fot oligomerization reactions via the Aufbau propagation reaction and as a catalyst for aqueous polymerization reactions using oxygen as a co catalyst. It is used as a catalyst for dl-selective pinacol-type coupling reactions, as an affecter of crystal growth of calcium carbonate and and as an inhibitor of human topoisomerase II enzyme with antitumor activity. | [Uses]
Vanadocene dichloride is used like other metallocenes as a
catalyst, ultraviolet absorber, reducing agent, free radical
scavenger, antiknock agent in gasoline, and as a developmental
anticancer drug. | [reaction suitability]
core: vanadium
reagent type: catalyst | [Pharmaceutical Applications]
Vanadocene dichloride [( η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic .
Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis. | [Pharmaceutical Applications]
Vanadocene dichloride [(η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic. Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. |
|
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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Energy Chemical
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Maya High Purity Chemicals
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Sigma-Aldrich
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