| Identification | Back Directory | [Name]
Ketone Ester | [CAS]
1208313-97-6 | [Synonyms]
R-BHB
BD-AcAc 2
Ketone Ester
(R)-(R)-3-hydroxybutyl 3-hydroxybutanoate
[(3R)-3-hydroxybutyl] (3R)-3-hydroxybutanoate
(3R)-3-Hydroxybutanoic acid (3R)-3-hydroxybutyl ester
Butanoic acid, 3-hydroxy-, (3R)-3-hydroxybutyl ester, (3R)- | [Molecular Formula]
C8H16O4 | [MDL Number]
MFCD22417094 | [MOL File]
1208313-97-6.mol | [Molecular Weight]
176.21 |
| Chemical Properties | Back Directory | [Boiling point ]
269℃ | [density ]
1.102 | [Fp ]
101℃ | [storage temp. ]
Store at -20°C | [solubility ]
Methyl Acetate: 50 mg/ml | [pka]
14.38±0.20(Predicted) | [InChI]
InChI=1S/C8H16O4/c1-6(9)3-4-12-8(11)5-7(2)10/h6-7,9-10H,3-5H2,1-2H3/t6-,7-/m1/s1 | [InChIKey]
AOWPVIWVMWUSBD-RNFRBKRXSA-N | [SMILES]
C(OCC[C@H](O)C)(=O)C[C@H](O)C |
| Hazard Information | Back Directory | [Uses]
Ketone ester(1208313-97-6) is exogenous ketone bodies that may promote ketosis in humans. Animal models demonstrate that ketone ester exert beneficial effects in Alzheimer's disease, effectively reducing amyloid accumulation, neurofibrillary tangles, and tau, while improving learning and memory.
| [Preparation]
Ketone ester can be prepared by reacting (3R)-3-hydroxybutyl methyl ester with tert-butyl dimethylchlorosilane.
 | [benefits]
Ketone esters can help with muscle recovery after exercising. They increase the rate of energy store replenishment in the body and support the process of rebuilding muscles. They also decrease the amount of muscle breakdown. The various forms of ketone esters that have been utilized include R,S-1,3-butanediol diacetoacetate (BD-AcAc2, ketone diester), D-β-hydroxybutyrate-(R)-1,3 butanediol (ketone monoester), and Bis-hexanoyl (R)-1,3-butanediol (BH-BD), among others.? | [Biological Activity]
Ketone ester–enriched diets that induce sustained ketonemia reduce pathological cardiac remodeling and enhance ventricular function in multiple heart failure models across both mice and rats using both prevention and treatment strategies. |
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