| Identification | Back Directory | [Name]
SARAFOTOXIN S6B | [CAS]
120972-53-4 | [Synonyms]
SRTX-B
SARAFOTOXIN B
Sarafotoxin 6b
SARAFOTOXIN S6B
CSCKDMTDKECLYFCHQDVIW
Sarafotoxin B|SARAFOTOXIN S6B
M.W. 2564.00 C110H159N27O34S5
SARAFOTOXIN B (ATRACTASPIS ENGADDENSIS)
SARAFOTOXIN S6B (ATRACTASPIS ENGADDENSIS)
SARAFOTOXIN S6B ATRACTASPIS ENGADDENSIS SEQUENCE
Sarafotoxin S 6B (reduced), cyclic (1-15),(3-11)-bis(disulfide)
CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-TYR-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP
H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-TYR-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH
H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-TYR-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH-OH
CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-TYR-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP (DISULFIDE BRIDGE: CYS1-CYS15, CYS3-CYS11)
Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11) | [Molecular Formula]
C110H159N27O34S5 | [MDL Number]
MFCD00153553 | [MOL File]
120972-53-4.mol | [Molecular Weight]
2563.93 |
| Chemical Properties | Back Directory | [Boiling point ]
2570.1±65.0 °C(Predicted) | [density ]
1.298±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [Sequence]
Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11) |
| Hazard Information | Back Directory | [Uses]
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the Ki values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively[1]. | [References]
[1] P S Devadason et al. Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery. Br J Pharmacol. 1997 May;121(2):253-63. DOI:10.1038/sj.bjp.0701126 |
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