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34273-10-4

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34273-10-4 Structure

34273-10-4 Structure
IdentificationBack Directory
[Name]

SARALASIN
[CAS]

34273-10-4
[Synonyms]

SARALASIN
SARALASIN USP/EP/BP
M.W. 912.05 C42H65N13O10
(SAR1,VAL5,ALA8)-ANGIOTENSIN II
SAR-ARG-VAL-TYR-VAL-HIS-PRO-ALA
SAR-ARG-VAL-TYR-VAL-HIS-PRO-ALA-OH
[SAR1,VAL5, ALA8]ANGIOTENSIN II, HUMAN
[Sar1,Val5,Ala8]angiotensin II【rabbit】
(Sar1,Val5,Ala8)-Angiotensin II Saralasin
Saralasin/[Sar1,Val5, Ala8] Angiotensin II
SAR-ARG-VAL-TYR-VAL-HIS-PRO-ALA: SAR-RVYVHPA
Sar-L-Arg-L-Val-L-Tyr-L-Val-L-His-L-Pro-L-Ala-OH
[sar1, val5, ala8]-angiotensin ii acetate hydrate
[Sar1, Val5, Ala8]-AngiotensinII hydrate acetate salt
[Sar1, Val5, Ala8]-Angiotensin II acetate salt hydrate
L-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-
[Molecular Formula]

C42H65N13O10
[MDL Number]

MFCD00167510
[MOL File]

34273-10-4.mol
[Molecular Weight]

912.05
Chemical PropertiesBack Directory
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

−20°C
[form ]

powder
[pka]

3.70±0.10(Predicted)
[Sequence]

{Sar}-Arg-Val-Tyr-Val-His-Pro-Ala
[CAS DataBase Reference]

34273-10-4
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Antihypertensive.
[Definition]

ChEBI:Saralasin is an oligopeptide.
[Brand name]

Sarenin (Procter & Gamble).
[in vivo]

Saralasin (intravenous injection, 5-50 μg/kg, a single dose) ameliorates the oxidative stress and tissue injury in cerulein-induced pancreatitis[5].
Saralasin (subcutaneous injection, 10 and 30 mg/kg, a single dose) increases serum renin activity (SRA) in normal, conscious rats, without markedly altering blood pressure or heart rate[6].

Animal Model:Cerulein-induced acute pancreatitis rats model[5]
Dosage:5, 10, 20, and 50 μg/kg, a single dose.
Administration:Intravenous injection
Result:Restored the pancreatic morphological characteristics to the control level.
Reduced pancreatic injury and suppressed the glutathione depletion induced by cerulean.
Animal Model:Male Sprague-Dawley rats[6]
Dosage:10 and 30 mg/kg, a single dose.
Administration:Subcutaneous injection
Result:Stimulated renin release without altering blood pressure or heart rate at the time of measuring serum renin levels 20 minutes after injection.
Spectrum DetailBack Directory
[Spectrum Detail]

SARALASIN(34273-10-4)MS
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