ChemicalBook--->CAS DataBase List--->121577-32-0

121577-32-0

Request For Quotation
121577-32-0 Structure

121577-32-0 Structure
IdentificationBack Directory
[Name]

Gatifloxacinacid
[CAS]

121577-32-0
[Synonyms]

Gatifloxacinacid
AM 1155 hydrochloride
PD 135432 hydrochloride)
BMS-206584 (hydrochloride)
BMS 206584-01 hydrochloride
Gatifloxacin hydrochloride (AM 1155 hydrochloride
AM 1155 HYDROCHLORIDE;BMS 206584-01 HYDROCHLORIDE;PD 135432 HYDROCHLORIDE
3-Quinolinecarboxylicacid,1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1)
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-, Monohydrochloride (9CI)
[Molecular Formula]

C19H22FN3O4.ClH
[MDL Number]

MFCD09838901
[MOL File]

121577-32-0.mol
[Molecular Weight]

411.859
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
[Biological Activity]

Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a potent fluoroquinolone antibiotic with broad-spectrum antimicrobial activity.
[in vivo]

Gatifloxacin hydrochloride (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad with Nocardia brasiliensis .

< p>

Animal Model: Female BALB/c mice with Nocardia brasiliensis in the right hind footpad
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 3 times a day; 30 days
Result: Reduced the production of lesions in mice.
[target]

Topoisomerase II

36.7 μM ()

[IC 50]

Quinolone; Topoisomerase II: 36.7 μM ()
[storage]

Store at -20°C
[References]

[1] Takei M, et al. Inhibitory activities of Gatifloxacin hydrochloride (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.Antimicrob Agents Chemother.?1998 Oct;42(10):2678-81. DOI:10.1128/AAC.42.10.2678
[2] Fukuda H, et al. Antibacterial activity of Gatifloxacin hydrochloride (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother.?1998 Aug;42(8):1917-22. DOI:10.1128/AAC.42.8.1917
[3] Yamada C, et al. Gatifloxacin hydrochloride?acutely?stimulates?insulin?secretion?and?chronically?suppresses?insulin?biosynthesis. Eur J Pharmacol.?2006 Dec 28;553(1-3):67-72. Epub 2006 Sep 28. DOI:10.1016/j.ejphar.2006.09.043
[4] Daw-Garza A, et al. In?vivo?therapeutic?effect?of?Gatifloxacin mesylate?on?BALB/c?mice?infected?with?Nocardia?brasiliensis.Antimicrob Agents Chemother.?2008 Apr;52(4):1549-50. DOI:10.1128/AAC.00148-08
Spectrum DetailBack Directory
[Spectrum Detail]

Gatifloxacinacid(121577-32-0)1HNMR
121577-32-0 suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Telephone: 18149758185 18149758185
Website: www.caerulumpharma.com
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-164-7117 18317119277
Website: www.bidepharm.com
Company Name: LETOPHARM LIMITED  
Telephone: +86-21-5821 5861
Website: www.letopharm.com
Company Name: Chizhou Kailong Import and Export Trade Co., Ltd.  
Telephone:
Website: www.chemicalbook.com/ShowSupplierProductsList16778/0_EN.htm
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 18916372613
Website: www.shyuanye.com
Company Name: Amadis Chemical Company Limited  
Telephone: 571-89925085
Website: http://www.amadischem.com
Company Name: Aikon International Limited  
Telephone: 025-58859352 15955137747
Website: www.aikonchem.com
Company Name: Nanjing the parson's chemical technology co., LTD  
Telephone: 025-58786926 18951781718
Website: http://www.epaisen.com/
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Telephone: 15911056312
Website: www.bio-fount.com
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD  
Telephone: 86-571-88216897,88216896 13588875226
Website: www.hzclap.com/en
Company Name: Jinan Ruisi Pharmaceutical Technology Co., LTD  
Telephone: 0531-0531-69900633 19963472814
Website: https://www.chemicalbook.com/ShowSupplierProductsList31265/0_EN.htm
Company Name: Shanghai Luofa Biochemical Technology Co., Ltd.  
Telephone: 021-51111890 15317326293
Website: www.molnova.cn/
Company Name: Energy Chemical  
Telephone: 400-0056266
Website: www.energy-chemical.com
Company Name: MedBioPharmaceutical Technology Inc  
Telephone: 021-69568360 18916172912
Website: http://www.med-bio.cn/
Company Name: cjbscvictory  
Telephone: 13348960310 13348960310
Website: www.weikeqi-biotech.com/
Company Name: Shanghai Sunway Pharmaceutical Technology Co.,Ltd.  
Telephone: 13611835272 13611835272
Website: www.sunwaypharm.cn/
Company Name: ChemeGen  
Telephone: 18818260767
Website: https://www.chemegen.com
Tags:121577-32-0 Related Product Information
85721-33-1 112811-59-3 86393-32-0