| Identification | More | [Name]
Ciprofloxacin hydrochloride hydrate | [CAS]
86393-32-0 | [Synonyms]
3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE
CIPROFLOXACIN HCL
CIPROFLOXACIN HYDROCHLORIDE
CIPROFLOXACIN HCL/ CIPROFLOXACIN MONOHYDROCHLORIDE
CIPROFLOXACIN HCL USP
CIPROFLOXACINHYDROCHLORIDE,USP
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride hydrate
Ciprofloxacin hydrochloride hydrate
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride monohydrate | [EINECS(EC#)]
617-845-1 | [Molecular Formula]
C17H21ClFN3O4 | [MDL Number]
MFCD00079044 | [Molecular Weight]
385.82 | [MOL File]
86393-32-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale yellow, crystalline, slightly hygroscopic powder. | [Melting point ]
318-320 °C | [RTECS ]
VB1993800 | [storage temp. ]
0-6°C | [solubility ]
Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol, practically insoluble in acetone, in ethyl acetate and in methylene chloride. | [form ]
neat | [color ]
White to Light yellow | [PH]
pH (25g/l, 25℃) 3.0～4.5 | [Water Solubility ]
Soluble in water (35mg/ml). | [Merck ]
2314 | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2 | [InChIKey]
DIOIOSKKIYDRIQ-UHFFFAOYSA-N | [SMILES]
O.Cl.OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O | [CAS DataBase Reference]
86393-32-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow, crystalline, slightly hygroscopic powder. | [Uses]
Ciprofloxacin hydrochloride has been suggested as a treatment for a wide range of infections caused by susceptible organisms including infections of urinary, respiratory, and gastrointestinal tracts, gonorrhoea and septicaemia. Nalidixic acid analogue. | [Uses]
Fluoroquinolone antibacterial. | [Application]
Ciprofloxacin hydrochloride hydrate is a broad-spectrum antibiotic that inhibits bacterial DNA gyrase and blocks DNA synthesis and replication, resulting in bacterial death. It has strong antibacterial activity against Escherichia coli, Klebsiella and other Enterobacteriaceae; the antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae is better than norfloxacin and pefloxacin. | [Definition]
ChEBI: The monohydrate form of ciprofloxacin monohydrochloride. | [Brand name]
Ciloxan (Alcon); Cipro (Bayer); Proquin (Esprit). | [General Description]
Ciprofloxacin HCl is a fluoroquinolone antibiotic agent, which shows a broad spectrum of antibacterial activity against gram positive and gram negative bacteria. | [Synthesis]
Ciprofloxacin hydrochloride hydrate is prepared via continuous flow synthesis starting from simple building blocks through an eight-step sequence involving sequential filtrations and offline acidifications, as well as by offline pH adjustment, filtration, and crystallization from ciprofloxacin sodium salt produced through a rapid assembly of five building blocks[1]. | [in vitro]
Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC 90 of 0.03 μg/mL. | [in vivo]
Ciprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS. | [References]
[1]Lin, H., Dai, C., Jamison, T. F., & Jensen, K. F. (2017). A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow. Angewandte Chemie International Edition, 56(30), 8870–8873. https://doi.org/10.1002/anie.201703812 |
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Spectrum Chemical Manufacturing Corp.
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