ChemicalBook--->CAS DataBase List--->121584-18-7

121584-18-7

121584-18-7 Structure

121584-18-7 Structure
IdentificationBack Directory
[Name]

Valspodar
[CAS]

121584-18-7
[Synonyms]

CS-51
AMdray
Psc 833
Valpodar
Valspodar
Sdz psc 833
Sdz-psc-833
Valspodar, >=98%
PSC833(Valspodar)
Valspodar (PSC-833)
PSC 833; PSC-833; PSC833
Valspodar(PSC-833,AMdray)
3'-Keto-bmt(1)-Val(2)-cyclosporin a
PSC833 - Specific MDR1/P-gp Inhibitor
[3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin
6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D
6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D
6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA
Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine-
6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A
Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-
Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]
[EINECS(EC#)]

1312995-182-4
[Molecular Formula]

C63H111N11O12
[MDL Number]

MFCD00907207
[MOL File]

121584-18-7.mol
[Molecular Weight]

1214.62
Chemical PropertiesBack Directory
[Melting point ]

143-145°C
[alpha ]

D20 -255.1° (c = 0.5 in CHCl3)
[Boiling point ]

1290.1±65.0 °C(Predicted)
[density ]

1.015±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

powder
[pka]

12.45±0.70(Predicted)
[color ]

white to beige
[InChIKey]

YJDYDFNKCBANTM-QCWCSKBGSA-N
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine (Item No. 11764), daunorubicin (Item No. 14159), doxorubicin (Item No. 15007), and etoposide (Item No. 12092), respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.
[Chemical Properties]

White Solid
[Uses]

Antineoplastic adjunct (chemosensitizer).
[Definition]

ChEBI: SDZ PSC 833 is a homodetic cyclic peptide.
[Brand name]

Amdray (Novartis).
[Biochem/physiol Actions]

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.
[Cytotoxicity]

Cells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].
[storage]

Store at -20°C
[References]

[1] Friedenberg W, et al. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95). Cancer, 2006; 106: 830-838.
[2] Parsons J, et al. Valspodar limits human cytomegalovirus infection and dissemination. Antiviral Research, 2021; 193: 105124.
Spectrum DetailBack Directory
[Spectrum Detail]

Valspodar(121584-18-7)MS
121584-18-7 suppliers list
Company Name: BOC Sciences
Tel: 16314854226; +16314854226 , +16314854226
Website: https://www.bocsci.com/
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: +86-15542445688
Website: http://www.alphabiopharm.com/
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: Biochempartner
Tel: 0086-13720134139
Website: www.biochempartner.com
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Baoji Guokang Bio-Technology Co., Ltd.
Tel: 0917-3909592 13892490616 , 13892490616
Website: http://www.gk-bio.com
Company Name: Nextpeptide Inc
Tel: +86-0571-81612335 +8613336028439 , +8613336028439
Website: http://www.nextpeptide.com/
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054 , 13417589054
Website: www.chemicalbook.com/ShowSupplierProductsList1962465/0.htm
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501 , +undefined18621343501
Website: www.acmec.com.cn/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139 , +8613720134139
Website: http://www.jknbiochem.com/
Company Name: Shanghai Likang New Materials Co., Limited
Tel: +86-16631818819 +86-17736933208 , +86-17736933208
Website:
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel: +8613817748580 , +8613817748580
Website: www.kean-chem.com
Tags:121584-18-7 Related Product Information
1000025-07-9 67469-78-7 656247-17-5 5428-80-8 330808-88-3 443913-73-3 1415562-82-1 446859-33-2 1415562-83-2 252917-06-9