| Identification | Back Directory | [Name]
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide | [CAS]
1216626-17-3 | [Synonyms]
[2H5]-Amisulpride
Amisulpride Impurity 27
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
Amisulpride Hydrochloride D5Q: What is
Amisulpride Hydrochloride D5 Q: What is the CAS Number of
Amisulpride Hydrochloride D5 Q: What is the storage condition of
Amisulpride Hydrochloride D5 Q: What are the applications of
Amisulpride Hydrochloride D5 | [Molecular Formula]
C17H22D5N3O4S | [MOL File]
1216626-17-3.mol | [Molecular Weight]
374.51 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: slightly soluble,Methanol: slightly soluble | [form ]
A solid | [color ]
White to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
Amisulpride-d5 is intended for use as an internal standard for the quantification of amisulpride by GC- or LC-MS. Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively). It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively). It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as reduces stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress. | [Uses]
Labelled Amisulpride (A633250). Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist. | [IC 50]
D3 Receptor | [storage]
Store at -20°C | [References]
[1] ATHEIR I ABBAS. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo.[J]. Psychopharmacology, 2009: 119-128. DOI: 10.1007/s00213-009-1521-8
[2] H SCHOEMAKER. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 280 1: 83-97.
[3] M PAPP J W. Antidepressant-like activity of amisulpride in two animal models of depression.[J]. Journal of Psychopharmacology, 2000, 14 1: 46-52. DOI: 10.1177/026988110001400106 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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