| Identification | More | [Name]
CALCIUM PHOSPHATE TRIBASIC | [CAS]
12167-74-7 | [Synonyms]
ALPHA-TCP
ALPHA-TRI-CALCIUM PHOSPHATE
APATITE ALPHA-TCP, MONOCLINIC
APATITE BETA-TCP, TRICLINIC
APATITE FAP, HEXACLINIC
BETA-CALCIUM PHOSPHATE TRIBASIC
BETA-TRICALCIUM PHOSPHATE
CALCIUM HYDROXIDE PHOSPHATE
CALCIUM ORTHOPHOSPHATE
CALCIUM PHOSPHATE
CALCIUM PHOSPHATE HYDROXIDE
CALCIUM PHOSPHATE PRECIPITATED ON CELLULOSE
CALCIUM PHOSPHATE TRIBASIC
CELLULOSE HYDROXYAPATIT
PENTA-CALCIUM HYDROXIDE TRIPHOSPHATE
TERT-CALCIUM PHOSPHATE
TRI-CALCIUM DI-ORTHOPHOSPHATE
TRI-CALCIUM (ORTHO)PHOSPHATE
TRI-CALCIUM PHOSPHATE
TRI-CALCIUM PHOSPHATE (BETA-FORM) | [EINECS(EC#)]
231-840-8 | [Molecular Formula]
Ca3O8P2 | [MDL Number]
MFCD00015984 | [Molecular Weight]
310.18 | [MOL File]
12167-74-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
1100 °C(lit.)
| [bulk density]
2-6g/cm3 | [density ]
1.038 g/mL at 25 °C | [storage temp. ]
2-8°C
| [solubility ]
Soluble in 1 M Hydrochloric acid. | [form ]
aqueous suspension
| [color ]
White | [PH]
4-6 | [Water Solubility ]
Partially soluble in water. | [Merck ]
1694 | [InChI]
1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10 | [InChIKey]
XYJRXVWERLGGKC-UHFFFAOYSA-D | [SMILES]
[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O | [CAS DataBase Reference]
12167-74-7(CAS DataBase Reference) | [EPA Substance Registry System]
Calcium hydroxide phosphate (12167-74-7) |
| Hazard Information | Back Directory | [Chemical Properties]
col hexagonal crystal(s) [CRC10] | [Uses]
Hydroxyapatite nanopowders, incorporated in biodegradable polymer composites1 or deposited on biocompatible substrates,2 have been shown to promote adhesions and proliferation of bone-forming (osteoblast) cells. | [Uses]
Si-substituted hydroxyapatite (Si-HAp) nanopowder can be incorporated in biodegradable polymer composites or deposited on biocompatible surfaces similar to pure HAp nanopowder (cat. no. 677418). Biological activity of HAp was shown to be enhanced by substitution of silicon ions into a fraction of HAp lattice phosphate sites.1,2 | [Application]
Calcium phosphate tribasic is the mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis. Employed in tissue replacement for repairing bony defects and acts as drug carrier for drug delivery to the bone. Hydroxyapatite nanopowders, incorporated in biodegradable polymer composites or deposited on biocompatible substrates, have been shown to promote adhesions and proliferation of bone-forming (osteoblast) cells. It is also the starting material for the production of phosphoric acid and fertilizers. | [Production Methods]
Tribasic calcium phosphate occurs naturally as the minerals
hydroxylapatite, voelicherite, and whitlockite. Commercially, it is
prepared by treating phosphate-containing rock with sulfuric acid.
Tribasic calcium phosphate powder is then precipitated by the
addition of calcium hydroxide. Tribasic calcium phosphate is
alternatively prepared by treating calcium hydroxide from limestone
with purified phosphoric acid. It may also be obtained from
calcined animal bones. Some tribasic calcium phosphate products
may be prepared in coarser, directly compressible forms by
granulating the powder using roller compaction or spray drying. | [General Description]
Hydroxyapatite is a key inorganic phosphate that has chemical and structural resemblance to bone. HAp is a popular biomaterial which finds use as a bone or teeth replacement and repair, hard tissue repair. | [Flammability and Explosibility]
Nonflammable | [Pharmaceutical Applications]
Tribasic calcium phosphate is widely used as a capsule diluent and
tablet filler/binder in either direct-compression or wet-granulation
processes. The primary bonding mechanism in compaction is plastic
deformation. As with dibasic calcium phosphate, a lubricant and a
disintegrant should usually be incorporated in capsule or tablet
formulations that include tribasic calcium phosphate. In some cases
tribasic calcium phosphate has been used as a disintegrant.It is
most widely used in vitamin and mineral preparations as a filler
and as a binder. It is a source of both calcium and phosphorus, the
two main osteogenic minerals for bone health. The bioavailability
of the calcium is well known to be improved by the presence of
cholecalciferol. Recent research reports that combinations of
tribasic calcium phosphate and vitamin D3 are a cost-effective
advance in bone fracture prevention.
In food applications, tribasic calcium phosphate powder is
widely used as an anticaking agent. | [Safety]
Tribasic calcium phosphate is widely used in oral pharmaceutical
formulations and food products, and is generally regarded as
nontoxic and nonirritant at the levels employed as a pharmaceutical
excipient.
Ingestion or inhalation of excessive quantities may result in the
deposition of tribasic calcium phosphate crystals in tissues. These
crystals may lead to inflammation and cause tissue lesions in the
areas of deposition.
Oral ingestion of very large quantities of tribasic calcium
phosphate may cause abdominal discomfort such as nausea and
vomiting.
No teratogenic effects were found in chicken embryos exposed to
a dose of 2.5 mg of tribasic calcium phosphate.
LD50 (rat, oral): >1 g/kg | [storage]
Tribasic calcium phosphate is a chemically stable material, and is
also not liable to cake during storage.
The bulk material should be stored in a well-closed container in a
cool, dry place. | [Incompatibilities]
All calcium salts are incompatible with tetracycline antibiotics.
Tribasic calcium phosphate is incompatible with tocopheryl acetate
(but not tocopheryl succinate). Tribasic calcium phosphate may
form sparingly soluble phosphates with hormones. | [Regulatory Status]
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral capsules
and tablets). Included in nonparenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313-P261-P304+P340-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
3
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
2835260000 | [Storage Class]
13 - Non Combustible Solids |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|