| Identification | Back Directory | [Name]
SARAFOTOXIN S6C | [CAS]
121695-87-2 | [Synonyms]
SRTX-C
SRTX-C, S6C
SARAFOTOXIN C
SARAFOTOXIN 6C
SARAFOTOXIN S6C
CTCNDMTDEECLNFCHQDVIW
Sarafotoxin C, SRTX-C
Sarafotoxin S6c >=97% (HPLC)
M.W. 2516.00 C103H147N37O27S5
Sarafotoxin C trifluoroacetate salt
SARAFOTOXIN 6C SYNTHETIC >99% PURITY
SARAFOTOXIN C (ATRACTASPIS ENGADDENSIS)
SARAFOTOXIN S6C, ATRACTASPSIS ENGADDENSIS
SARAFOTOXIN S6C (ATRACTASPIS ENGADDENSIS)
SARAFOTOXIN 6C, (LYS4) SYNTHETIC >99% PU RITY
CTCNDMTDEECLNFCHQDVIW (DISULFIDE BRIDGE: 1-15 AND 3-11)
CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP
H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH
H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH-OH
H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)
CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP(DISULFIDE BRIDGE: CYS1-CYS15, CYS3-CYS11)
Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-asparaginyl-L-α-aspartyl-L-methionyl-L-threonyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-cysteinyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) | [Molecular Formula]
C103H147N27O37S5 | [MDL Number]
MFCD00161501 | [MOL File]
121695-87-2.mol | [Molecular Weight]
2515.75 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: Sparingly Soluble: 1-10 mg/ml | [form ]
solid | [color ]
white | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1]. | [Biochem/physiol Actions]
Sarafotoxin S6c is an endothelin ETB agonist. It is a peptide isotoxin with strong vasoconstrictor activity, obtained from the Middle Eastern snake, Atractaspis engaddensi. The toxin is composed of 21 amino acids. | [in vivo]
Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1]. | Animal Model: | Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks[1] | | Dosage: | 1 pM-1 mM | | Administration: | | | Result: | Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident.
Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.
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| [storage]
-20°C | [References]
[1] MacLean MR, et al. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. DOI:10.1097/00005344-199511000-00020 |
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