| Identification | Back Directory | [Name]
Spiro[benzo[4,5]cyclodeca[1,2-b]furan-12(2H),2'-oxiran]-2-one, 8,9,13-tris(acetyloxy)-4-chloro-1,3a,4,5,8,8a,9,10,11,12a,13,13a-dodecahydro-13a-hydroxy-1,8a-dimethyl-5-methylene-, (1R,2'R,3aR,4S,6Z,8S,8aR,9S,12aS,13S,13aR)- | [CAS]
121769-82-2 | [Synonyms]
Spiro[benzo[4,5]cyclodeca[1,2-b]furan-12(2H),2'-oxiran]-2-one, 8,9,13-tris(acetyloxy)-4-chloro-1,3a,4,5,8,8a,9,10,11,12a,13,13a-dodecahydro-13a-hydroxy-1,8a-dimethyl-5-methylene-, (1R,2'R,3aR,4S,6Z,8S,8aR,9S,12aS,13S,13aR)- | [Molecular Formula]
C26H33ClO10 | [MOL File]
121769-82-2.mol | [Molecular Weight]
540.99 |
| Hazard Information | Back Directory | [Uses]
Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52?μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent[1]. | [References]
[1] Jiru Wu, et al. Briarane-type diterpenoids from a gorgonian coral Ellisella sp. with anti-HBV activities. Bioorg Chem. 2020 Dec;105:104423. DOI:10.1016/j.bioorg.2020.104423 |
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