| Identification | Back Directory | [Name]
PF-04979064 | [CAS]
1220699-06-8 | [Synonyms]
CS-2664
PF-04979064
PF-04979064 ≥95%
PF 04979064;PF04979064
PF-04979064 >=98% (HPLC)
(S)-1-(1-(2-hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one
1,3-Dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)- | [Molecular Formula]
C24H26N6O3 | [MOL File]
1220699-06-8.mol | [Molecular Weight]
446.5 |
| Chemical Properties | Back Directory | [Boiling point ]
682.0±55.0 °C(Predicted) | [density ]
1.355±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 11 mg/mL (24.64 mM) | [form ]
Solid | [pka]
13.95±0.20(Predicted) | [color ]
White to yellow | [InChIKey]
GACQNUHFDBEIQH-HNNXBMFYSA-N | [SMILES]
CN(C(N1C2CCN(C([C@@H](O)C)=O)CC2)=O)C3=C1C4=NC(C5=CN=C(C)C=C5)=CC=C4N=C3 |
| Hazard Information | Back Directory | [Uses]
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively. | [Biological Activity]
PF-04979064 is an orally availablepotent and selective PI3K/mTOR dual kinase inhibitor th at potently inhibits tumor growth in mouse xenografts. | [in vivo]
PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%[1]. | [IC 50]
PI3Kα: 0.13 nM (Ki); PI3Kγ: 0.111 nM (Ki); PI3Kδ: 0.122 nM (Ki); mTOR: 1.42 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Cheng H et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 2012 Nov 7, 4(1):91-7. DOI:10.1021/ml300309h |
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| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|