ChemicalBook--->CAS DataBase List--->72882-78-1

72882-78-1

72882-78-1 Structure

72882-78-1 Structure
IdentificationBack Directory
[Name]

PF-9366
[CAS]

72882-78-1
[Synonyms]

PF-9366
CS-2703
PF 9366 NEW
PF-9366; PF 9366; PF9366;72882-78-1
[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-
[Molecular Formula]

C20H19ClN4
[MDL Number]

MFCD31630724
[MOL File]

72882-78-1.mol
[Molecular Weight]

350.84
Chemical PropertiesBack Directory
[Melting point ]

182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
[density ]

1.25±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

Soluble in DMSO (up to 20 mg/ml).
[form ]

solid
[pka]

8.75±0.28(Predicted)
[color ]

Beige
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard InformationBack Directory
[Description]

PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.
[Uses]

PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.
[storage]

Store at -20°C
[References]

1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785
Spectrum DetailBack Directory
[Spectrum Detail]

PF-9366(72882-78-1)1HNMR
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