| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [color ]
white to beige | [SMILES]
[Cl-][Au+3]1([N]2=C(C=C(C=C2)OC)C3=[N]1C=CC(OC)=C3)[Cl-].F[P-](F)(F)(F)(F)F |
| Hazard Information | Back Directory | [Uses]
AubipyOMe serves as a potent inhibitor of tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme found in activated osteoclasts and macrophages, demonstrating IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b, while effectively inhibiting TRAP activity in extracts from murine macrophages and human lung tissue. | [Biological Activity]
AubipyOMe is a potent inhibitor of tartrate resistant acid phosphatase (TRAP/ACP5)a metalloenzyme expressed in activated osteoclasts and in macrophages. AubipyOMe exhibited IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b and inhibited TRAP activity in murine macrophage and human lung tissue extracts. | [References]
[1] Molecular and functional properties of P2X receptorsrecent progress and persisting challenges
[2] Covalent binding of 3'-O-(4-benzoyl) benzoyl adenosine 5'-triphosphate (BzATP) to the isolated alpha and beta subunits and the alpha 3 beta 3 core complex of TF1
[3] P2X7 receptor inhibition increases CNTF in the subventricular zone, but not neurogenesis or neuroprotection after stroke in adult mice
[4] Osmotic surveillance mediates rapid wound closure through nucleotide release
[5] Benzophenone-ATP: A photoaffinity label for the active site of ATPasesTest1986
[6] Receptor-independent effects of 2(3)-O-(4-benzoylbenzoyl) ATP triethylammonium salt on cytosolic p
[7] P2times 7 Receptor in the Kidneys of Diabetic Rats Submitted to Aerobic Training or to N-Acetylcysteine Supplementation
[8] Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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