| Identification | Back Directory | [Name]
PS 423 | [CAS]
1221964-37-9 | [Synonyms]
PS 423
PS210AM
PS210-AM
PS 210 AM
Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-, 1,3-bis[(acetyloxy)methyl] ester | [Molecular Formula]
C25H23F3O9 | [MOL File]
1221964-37-9.mol | [Molecular Weight]
524.44 |
| Chemical Properties | Back Directory | [Boiling point ]
614.8±55.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.84±0.59(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PS423 is a prodrug of PS210, acting as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K. PS210 is a potent and selective PDK1 activator targeting the PIF binding pocket of PDK1[1]. | [References]
[1] Busschots K, et al. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19(9):1152-63. DOI:10.1016/j.chembiol.2012.07.017 |
|
|