| Identification | Back Directory | [Name]
4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- | [CAS]
1226443-41-9 | [Synonyms]
HQ461
4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-
cyclin K degrader,Cyclin dependent kinase,molecular glue,HQ461,HQ 461,HQ-461,CDK12 substrate phosphorylation,inhibit,CDK,Inhibitor,Molecular Glues,DNA damage | [Molecular Formula]
C15H15N5OS2 | [MOL File]
1226443-41-9.mol | [Molecular Weight]
345.44 |
| Chemical Properties | Back Directory | [density ]
1.436±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
8.11±0.50(Predicted) | [color ]
Gray to light brown | [InChI]
InChI=1S/C15H15N5OS2/c1-9-4-3-5-12(17-9)19-15-18-11(8-22-15)6-13(21)20-14-16-7-10(2)23-14/h3-5,7-8H,6H2,1-2H3,(H,16,20,21)(H,17,18,19) | [InChIKey]
QMRBCNQCRMTXBE-UHFFFAOYSA-N | [SMILES]
S1C=C(CC(NC2=NC=C(C)S2)=O)N=C1NC1=NC(C)=CC=C1 |
| Hazard Information | Back Directory | [Uses]
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1]. | [References]
[1] Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994. DOI:10.7554/eLife.59994 |
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