| Identification | Back Directory | [Name]
2-[4-[(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid | [CAS]
123021-85-2 | [Synonyms]
GPR35 agonist 3
GPR35 Agonist, Compound 10
GPR35 Agonist, Compound 10 >=98% (HPLC)
2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid
2-[4-[(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid
Acetic acid, 2-[4-[(2,4-dioxo-5-thiazolidinylidene)methyl]phenoxy]-
2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]p
henoxy}acetic acid | [Molecular Formula]
C12H9NO5S | [MDL Number]
MFCD01835940 | [MOL File]
123021-85-2.mol | [Molecular Weight]
279.27 |
| Chemical Properties | Back Directory | [density ]
1.550±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥5mg/mL at ~60°C | [form ]
powder | [pka]
3.08±0.10(Predicted) | [color ]
white to tan | [InChI]
1S/C12H9NO5S/c14-10(15)6-18-8-3-1-7(2-4-8)5-9-11(16)13-12(17)19-9/h1-5H,6H2,(H,14,15)(H,13,16,17)/b9-5- | [InChIKey]
WXMCOLGPDOYHNK-UITAMQMPSA-N | [SMILES]
OC(=O)COc1ccc(cc1)\C=C2/SC(=O)NC2=O |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36 | [Safety Statements ]
26 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
GPR35 Agonist, Compound 10, may be used in GPR35-mediated cell signaling studies. | [Biochem/physiol Actions]
GPR35 agonist Compound 10 is a GPR35 agonist the binds with higher affinity than other known agonists, such as kynurenic acid and zaprinast. Compound 10 was more potent than zaniprast (pEC50 = 5.3 vs 4.18) for recombinantly expressed human GPR35, and unlike zaprinast, is equipotent for human and rat GPR35 |
|
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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