| Identification | Back Directory | [Name]
4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine | [CAS]
123148-78-7 | [Synonyms]
EOS-62121
6-Chloro-7-iodo-deazapurine
4-Chloro-5-iodo-1H-pyrrol...
6-Chloro-7-iodo-7-deazapurine
6-Chloro-7-iodo-7-deazapurine >
6-Chloro-7-iodo-7-deazapurine,96%
4-CHLORO-5-IODO-7H-PYRROL[2,3]PYRIMIDINE
4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine
5-Iodo-4-chloro-7H-pyrrol[2,3-d]pyrimidine
4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
4-CHLORO-5-IODO-1H-PYRROLO [2,3-D] PYRIMIDINE
7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-5-iodo-
JR-13973, 4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, 95%
4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine ISO 9001：2015 REACH
4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine
6-Chloro-7-iodo-7-deazapurine | [EINECS(EC#)]
626-377-7 | [Molecular Formula]
C6H3ClIN3 | [MDL Number]
MFCD09263258 | [MOL File]
123148-78-7.mol | [Molecular Weight]
279.47 |
| Chemical Properties | Back Directory | [Melting point ]
179-183 °C | [Boiling point ]
241.0±50.0 °C(Predicted) | [density ]
2.47±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
9.61±0.20(Predicted) | [color ]
White to Orange to Green | [Water Solubility ]
Insoluble in water. | [Sensitive ]
Light Sensitive | [λmax]
305nm(H2O)(lit.) | [InChI]
InChI=1S/C6H3ClIN3/c7-5-4-3(8)1-9-6(4)11-2-10-5/h1-2H,(H,9,10,11) | [InChIKey]
CBWBJFJMNBPWAL-UHFFFAOYSA-N | [SMILES]
C1=NC(Cl)=C2C(I)=CNC2=N1 |
| Hazard Information | Back Directory | [Uses]
6-Chloro-7-iodo-7-deazapurine is used as pharmaceutical intermediate. | [Definition]
4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine, also known as 6-Chloro-7-iodo-7-deazapurine or 4-Chloro-5-iodo-1H-pyrrolo[2,3-d]pyrimidine, is a white solid that can be obtained by iodine reaction of 4-chloro-7h-pyrrole [2,3-d] pyrimidine with NIS.
| [Synthesis]
4-chloro-7h-pyrrole [2,3-d] pyrimidine (8.0 g, 52.32 mmol, 1.0 eq) was dissolved in DMF(40 mL) and NIS(15.7g, 57.55 mmol, 1.1eq) was added at 0℃. After stirring at room temperature overnight, 200 mL of saturated Na2S2O3 solution was added. The mixture was filtered, washed with water three times, and vacuum drying, to obtain 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine.
| [References]
[1] Patent: US2005/107312, 2005, A1
[2] Patent: US2005/215510, 2005, A1
[3] Patent: US2005/215511, 2005, A1
[4] Patent: US2005/215511, 2005, A1
[5] Patent: WO2012/158795, 2012, A1. Location in patent: Page/Page column 100 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Shangchem Co., Ltd.
|
| Telephone: |
+86-21-68182121 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList14031/0_EN.htm |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
|