| Identification | Back Directory | [Name]
5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine | [CAS]
22276-95-5 | [Synonyms]
5-Bromo-4-chloro-7H-pyrro...
5-broMo-4-chloro-7H-pyrrolo[2
7-BroMo-6-chloro-7-deazapurine
4-chloro-5-bromo-7H-pyrrolo[2,3-d]pyrimidine
5-bromo-4-chloro-1H-pyrrolo[2,3-d]pyrimidine
5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-
5-Bromo-4-chloro-7H-pyrrolo[2,3-D]pyrimidine ,98%
7-bromo-5-chloro-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C6H3BrClN3 | [MDL Number]
MFCD09702029
| [MOL File]
22276-95-5.mol | [Molecular Weight]
232.47 |
| Chemical Properties | Back Directory | [Melting point ]
221-225℃ | [Boiling point ]
221.0±50.0 °C(Predicted) | [density ]
2.15±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [pka]
9.43±0.20(Predicted) | [color ]
Yellow | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C6H3BrClN3/c7-3-1-9-6-4(3)5(8)10-2-11-6/h1-2H,(H,9,10,11) | [InChIKey]
OXLMTRZWMHIZBY-UHFFFAOYSA-N | [SMILES]
C1=NC(Cl)=C2C(Br)=CNC2=N1 | [CAS DataBase Reference]
22276-95-5 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301 | [Precautionary statements ]
P301+P310 | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [RIDADR ]
2811 | [WGK Germany ]
3 | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
2933599590 |
| Hazard Information | Back Directory | [Uses]
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. | [Synthesis]
4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) was dissolved in 75 mL of chloroform, followed by added 3.5 g (0.02 mol) of N-bromosuccinamide. The resulting mixture was refluxed for 1 h. After cooling to room temperature, the precipitate was removed by filtration and dried under reduced pressure to afford 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine.
![5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine](/NewsImg/2023-10-16/6383304681021769691683764.jpg "5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine") | [References]
[1] Organic Letters, 2003, vol. 5, # 20, p. 3587 - 3590
[2] Synthesis, 2011, # 9, p. 1442 - 1446
[3] Archiv der Pharmazie, 2016, vol. 349, # 5, p. 356 - 362
[4] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 543 - 551
[5] Patent: CN107556318, 2018, A. Location in patent: Paragraph 0101-0103; 0106; 0107 |
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