| Identification | Back Directory | [Name]
2'-O-Methylhelichrysetin | [CAS]
123316-64-3 | [Synonyms]
CH625
2'-O-Methylhelichrysetin
4,4'-Dihydroxy-2',6'-dimethoxychalcone
2-Propen-1-one, 1-(4-hydroxy-2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C17H16O5 | [MDL Number]
MFCD23103606 | [MOL File]
123316-64-3.mol | [Molecular Weight]
300.306 |
| Chemical Properties | Back Directory | [Melting point ]
192-193 °C | [Boiling point ]
556.0±50.0 °C(Predicted) | [density ]
1.279±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
7.18±0.25(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
4,4'-Dihydroxy-2',6'-dimethoxychalcone is a Chalcones product that can be isolated from the herbs of Alpinia galanga[1]. | [Definition]
ChEBI: 4,4'-Dihydroxy-2',6'-dimethoxychalcone is a member of phenols. | [Biological Activity]
CH625 is a potent and selective competitive inhibitor of CYP4X1 th at decreases tumor burdenincreases survival in glioma intracranial and subcutaneous model in rats. CH625 normalizes tumor vasculature in the C6 and GL261 gliomas through tumor-associated macrophages (TAMs) reprograming and inhibition of VEGF and TGF-β production. |
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