| Identification | Back Directory | [Name]
3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one | [CAS]
1233533-04-4 | [Synonyms]
CS-2453
kbNB142-70, >98%
3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
[1]Benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one, 3,4-dihydro-9-hydroxy-
kb-NB142-70 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
4-Hydroxy-8,14-dithia-11-azatricyclo[7.5.0.0^{2,7}]tetradeca-1(9),2,4,6-tetraen-10-one | [Molecular Formula]
C11H9NO2S2 | [MDL Number]
MFCD18086915 | [MOL File]
1233533-04-4.mol | [Molecular Weight]
251.32 |
| Chemical Properties | Back Directory | [Melting point ]
235-238℃ (decomposition) (water dichloromethane ) | [Boiling point ]
601.9±55.0 °C(Predicted) | [density ]
1.495±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
8.99±0.20(Predicted) | [color ]
white to beige | [InChI]
1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14) | [InChIKey]
DHUAGGSHTKPOHU-UHFFFAOYSA-N | [SMILES]
Oc1ccc2sc3C(=O)NCCSc3c2c1 |
| Hazard Information | Back Directory | [Uses]
kb NB 142-70 is a potent & selective protein kinase D inhibitor. | [Biological Activity]
kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer celland blocks migration of the prostate cancer lines PC3 and DU145. | [IC 50]
PKD1: 28.3 nM (IC50); PKD3: 53.2 nM (IC50); PKD2: 58.7 nM (IC50) | [storage]
Store at RT |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|