| Identification | Back Directory | [Name]
N-BOC-(METHYLAMINO)ACETALDEHYDE | [CAS]
123387-72-4 | [Synonyms]
N-Boc-(methyL
N-BOC-(METHYLAMINO)ACETALDEHYDE
N-Boc-2-(methylamino)acetaldehyde
ert-butylN-methyl-N-(2-oxoethyl)carbamate
tert-Butyl N-methyl-N-(2-oxoethyl)carbamate
O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate
N-tert-Butoxycarbonyl-(methylamino)acetaldehyde
N-methyl-N-(2-oxoethyl)-, 1,1-dimethylethyl ester
N-(tert-butoxycarbonyl)-N-MethylaMinoacetaldehyde
CARBAMIC ACID,N-METHYL-N-(2-OXOETHYL)-, 1,1-DIMETHYLETHYL ESTER | [Molecular Formula]
C8H15NO3 | [MDL Number]
MFCD08064267 | [MOL File]
123387-72-4.mol | [Molecular Weight]
173.21 |
| Chemical Properties | Back Directory | [Boiling point ]
218.2±19.0 °C(Predicted) | [density ]
1.026g/ml | [refractive index ]
1.44 | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [form ]
clear liquid | [pka]
-1.63±0.70(Predicted) | [color ]
Colorless to Light yellow | [Water Solubility ]
Slightly miscible with water. | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C8H15NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h6H,5H2,1-4H3 | [InChIKey]
MSWTVSDFEYSRMQ-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)N(C)CC=O |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Uses]
N-Boc-(methylamino)acetaldehyde is involved in the preparation of benzo[d]imidazole inhibitor of co-activator associated arginine methyltransferase. | [Synthesis]
General procedure for the synthesis of N-Boc-(methylamino)acetaldehyde from N-BOC-N-methylaminoethanol: (a) Dess-Martin periodontane (22 g, 52 mmol) was added batchwise to a solution of 2-(N-Boc-methylamino)ethanol (8.8 g, 50 mmol) dissolved in dichloromethane at 0 °C. The reaction mixture was naturally warmed to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution and sodium thiosulfate solution were added and stirring was continued for 0.5 hours. Subsequently, the organic phase was separated, washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate, and concentrated to give 9 g (quantitative yield) of the title compound N-Boc-(methylamino)acetaldehyde. The product was analyzed by GC-MS and showed m/z 174 (M + 1). | [References]
[1] Patent: WO2007/120098, 2007, A1. Location in patent: Page/Page column 88
[2] Patent: WO2013/68552, 2013, A1. Location in patent: Page/Page column 53
[3] ChemMedChem, 2015, vol. 10, # 3, p. 470 - 489
[4] Patent: WO2011/133039, 2011, A2. Location in patent: Page/Page column 202
[5] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 21, p. 3219 - 3225 |
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| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|