| Identification | More | [Name]
Boc-L-Hydroxyproline | [CAS]
13726-69-7 | [Synonyms]
(2S,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
BOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
BOC-HYDROXYPROLINE
BOC-HYP-OH
BOC-L-4-HYDROXYPROLINE
BOC-L-HYDROXYPROLINE
BOC-L-HYP-OH
BOC-L-T-4-HYDROXYPROLINE
BOC-L-TRANS-4-HYDROXYPROLINE
BOC-TRANS-4-HYDROXY-L-PROLINE
BOC-TRANS-HYP-OH
N-ALPHA-T-BOC-L-HYDROXYPROLINE
N-ALPHA-T-BOC-L-TRANS-4-HYDROXYPROLINE
N-ALPHA-T-BOC-TRANS-4-HYDROXY-L-PROLINE
N-ALPHA-T-BUTOXYCARBONYL-L-HYDROXYPROLINE
N-ALPHA-T-BUTOXYCARBONYL-TRANS-4-HYDROXY-L-PROLINE
N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-HYDROXYPROLINE
N-BOC-4-HYDROXY-L-PROLINE
N-BOC-L-4-HYDROXYPROLINE
N-BOC-L-TRANS-4-HYDROXYPROLINE | [EINECS(EC#)]
604-011-7 | [Molecular Formula]
C10H17NO5 | [MDL Number]
MFCD00053370 | [Molecular Weight]
231.25 | [MOL File]
13726-69-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
123-127 °C(lit.)
| [alpha ]
-78 º (in H2O) | [Boiling point ]
390.9±42.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [refractive index ]
-68 ° (C=1, MeOH) | [storage temp. ]
−20°C
| [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
3.80±0.40(Predicted) | [color ]
White to off-white | [Optical Rotation]
[α]20/D 53.5±2°, c = 1% in DMF | [Water Solubility ]
very faint turbidity | [BRN ]
4295484 | [Major Application]
peptide synthesis | [InChI]
1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7+/m1/s1 | [InChIKey]
BENKAPCDIOILGV-RQJHMYQMSA-N | [SMILES]
CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(O)=O | [CAS DataBase Reference]
13726-69-7(CAS DataBase Reference) | [EPA Substance Registry System]
13726-69-7(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
Boc-Hyp-OH is used in the preparation of hydroxyproline derivatives. It is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive. | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis | [Biological Activity]
Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | [Synthesis]
1. 18.1g L-proline, 10ml water was added to the reaction flask and stirred. Add 16g of sodium hydroxide configured 0.1 mol/L alkaline solution adjusted to alkaline. Then 8g of (Boc)2O was added to react for I hour,then 8g of (Boc)2O was added to react | [IC 50]
Non-cleavable Linker |
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