| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in water and to 100 mM in DMSO | [form ]
Powder | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3αβ(IC50= 4.1μM). Also shown to inhibit amyloid-βproduction in N2A-APP695cells. | [Uses]
(R)-DRF053 DiHydrochloride (cas# 1241675-76-2) is a useful research chemical.(R)-DRF053 Dihydrochloride was used for studying cancer treatments using combinations of CDK kinase and ERK inhibitors. | [IC 50]
CK1: 14 nM (IC50); CDK1/cyclinB1: 220 nM (IC50); Cdk5/p25: 80 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Abcam Limited
|
| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
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