| Identification | Back Directory | [Name]
1-Piperazinecarboxylic acid, 4-(5-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester | [CAS]
1245914-05-9 | [Synonyms]
tert-butyl 4-(5-aminopyridin-3-yl)piperazine-1-carboxylate
1,1-Dimethylethyl 4-(5-amino-3-pyridinyl)-1-piperazinecarboxylate
1-Piperazinecarboxylic acid, 4-(5-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester | [Molecular Formula]
C14H22N4O2 | [MOL File]
1245914-05-9.mol | [Molecular Weight]
278.35 |
| Hazard Information | Back Directory | [Uses]
1,1-Dimethylethyl 4-(5-amino-3-pyridinyl)-1-piperazinecarboxylate is the impurity of Palbociclib (HY-50767). Palbociclib is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively[1]. | [References]
[1] Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. PMID:15542782 |
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