| Identification | Back Directory | [Name]
5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine | [CAS]
1246535-95-4 | [Synonyms]
CB72666407
VS-5584 analog
Desmethyl-VS-5584
DESMETHYL VS 5584; DESMETHYL VS5584
5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine
5-[2-(morpholin-4-yl)-9-(propan-2-yl)-9H-purin-6-yl]pyrimidin-2-amine
5-[9-(1-Methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine
2-Pyrimidinamine, 5-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]- | [Molecular Formula]
C16H20N8O | [MDL Number]
MFCD27996045 | [MOL File]
1246535-95-4.mol | [Molecular Weight]
340.38 |
| Chemical Properties | Back Directory | [Boiling point ]
669.3±65.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: 0.5mg/mL | [form ]
A solid | [pka]
3.94±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
VS-5584 analog is a dual inhibitor of PI3Kα and mammalian target of rapamycin (mTOR; IC50s = 17 and 150 nM, respectively). It is a desmethyl analog of the dual PI3K/mTOR inhibitor VS-5584 . | [Uses]
An intermediate in the preparation of purine compounds as therapeutic kinase inhibitors. | [References]
[1] ANDERS POULSEN*. Structure and Ligand-Based Design of mTOR and PI3-Kinase Inhibitors Leading to the Clinical Candidates VS-5584 (SB2343) and SB2602[J]. Journal of Chemical Information and Modeling , 2014, 54 11: 3238-3250. DOI: 10.1021/ci500493m |
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