| Identification | Back Directory | [Name]
ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE | [CAS]
124755-24-4 | [Synonyms]
ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE
Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate 97%
Di(3,3,3-trifluoroethyl)(ethoxycarbonylmethyl)phosphonate
[Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid ethyl ester
[BIS-(2,2,2-TRIFLUORO-ETHOXY)-PHOSPHORYL]-ACETIC ACID METHYL ESTER
Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, ethyl ester | [Molecular Formula]
C8H11F6O5P | [MDL Number]
MFCD01318337 | [MOL File]
124755-24-4.mol | [Molecular Weight]
332.13 |
| Chemical Properties | Back Directory | [Boiling point ]
249-250 °C(lit.) | [density ]
1.403 g/mL at 25 °C(lit.) | [refractive index ]
n20/D 1.3730(lit.) | [Fp ]
>230 °F | [InChI]
InChI=1S/C8H11F6O5P/c1-2-17-6(15)3-20(16,18-4-7(9,10)11)19-5-8(12,13)14/h2-5H2,1H3 | [InChIKey]
HBYHPBCAZBLFTD-UHFFFAOYSA-N | [SMILES]
C(OCC)(=O)CP(OCC(F)(F)F)(OCC(F)(F)F)=O |
| Hazard Information | Back Directory | [Uses]
Ethyl [Bis(2,2,2-trifluoroethoxy)phosphinyl]acetate is a reagent used in the preparation of spiroketal EBC-23; an anticancer agent, scytonemin A; a novel calcium antagonist and other useful organic compounds. | [Synthesis]
To stirred solution of 18-crown-6 (4.40 g, 16.65 mmol), THF (20 mL), and bis
(2,2,2-trifluoroethyl) phosphite (1) (0.55 mL, 3.75 mmol), KHMDS (8.0 mL, 4.00 mmol,
0.5 M in toluene) was added via syringe in a dropwise manner at -78 oC. Ethyl
chloroacetate (0.35 mL, 3.30 mmol) was added to the flask after 15 min. The reaction
flask was allowed to warm to room temperature and stir for 4 hr. After standard workup
procedure, the crude product was then purified by flash column chromatography (2:1-1:1
hexanes:EtOAc, Rf
= 0.25 in 2:1 hexanes:EtOAc) yielding Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate (808 mg,
2.43 mmol, 73.4%) as a yellow syrup. |
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| Company Name: |
Energy Chemical
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021-021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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