| Identification | Back Directory | [Name]
METHOXYPOLYETHYLENE GLYCOL 5,000 PROPIONIC ACID | [CAS]
125220-94-2 | [Synonyms]
m-PEG12-acid
m-PEG16-acid
m-PEG24-acid
m-PEG25-acid
m-PEG37-acid
m-PEG49-acid
m-PEG12-COOH
m-PEG24-COOH
Methyl-PEG24-acid
mPEG24-propionic acid
mPEG11-propionic acid
Methyl-PEGn-CH2CH2COOH (n=12,24,25,49)
METHOXYPOLY(ETHYLENE GLYCOL) PROPIONIC ACID
METHOXYPOLYETHYLENE GLYCOL 5,000 PROPIONIC ACID
Polyethylene glycol 2-carboxyethyl methyl ether
Polyethylene glycol monomethyl ether propionic acid
MONO-METHYL POLYETHYLENE GLYCOL 5'000 PROPIONIC ACID
O-(2-CARBOXYETHYL)-O'-METHYLPOLYETHYLENE GLYCOL 5,000
mono-Methyl polyethylene glycol 5μ000 propionic acid, O-(2-Carboxyethyl)-Oμ-methylpolyethylene glycol 5,000 | [Molecular Formula]
MeO-PEG-C2H4CO2H | [MDL Number]
MFCD05665436 | [MOL File]
125220-94-2.mol |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
lumps | [α-end]
methoxy | [Ω-end]
carboxylic acid | [InChI]
InChI=1S/C6H12O4/c1-9-4-5-10-3-2-6(7)8/h2-5H2,1H3,(H,7,8) | [InChIKey]
KWMXBFIAGYXCCC-UHFFFAOYSA-N | [SMILES]
C(CC(=O)O)O{-}CC{+n}OC |
| Hazard Information | Back Directory | [Description]
m-PEG24-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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